Feeling horrible for what it was doing to everyone I love. It's hard to see people you love look at you with that much pain in their eyes.....
Both cancer cells and cars need fuel to move but in cancer cell the fuel is Oxidative stress
Search for: ( oxidative stress)
You will find that oxidative stress is( imbalance between the production and manifestation of reactive oxygen species )
First ,I didn’t understand this definition but, later I understand that >
THERE'S SOMETHING CALLED (ROS)REACTIVE OXYGEN SPECIES ..WHICH IS molecules that carry oxygen such as peroxides BUT, why we descriped this molecule by REACTIVE?
They are reactive as they contain unpaired valence shell electrons. during times of environmental stress (e.g., UV or heat exposure), ROS levels can increase dramatically
(N.B)Normal cells have low levels of ROS, in tune with their more modest metabolism, so they don't need high levels of the anti-oxidant enzymes
SO ..>: cancer cell depends on a hyperactive metabolism to fuel its rapid growth, it also depends on anti-oxidative enzymes to get over or to quench potentially toxic reactive oxygen species (ROS) generated by such high metabolic demand
SO, we can find a compound that blocks this response to oxidative stress selectively in cancer cells
Then I found that Scientists at the Broad Institute and Massachusetts General Hospital (MGH) have discovered this compound that blocks this response to oxidative stress which isThe plant-based compound piperlongumine (PL), derived from the fruit of a pepper plant found in southern India and southeast Asia, appears to kill cancer cells by jamming the machinery that dissipates high oxidative stress and the resulting ROS. Normal cells have low levels of ROS, in tune with their more modest metabolism, so they don't need high levels of the anti-oxidant enzymes that PL stymies once they pass a certain threshold.
THEY saw that PL induced cancer cell death independent of p53 gene's activity.
What's p53?
P53..........(protein that in humans is encoded by the TP53 gene)...There are specific genes in the cells of our bodies that normally help to prevent tumors from forming. One of these tumor-suppressor genes , called P53 ("p" for protein and "53" for its weight) was recently named "Molecule of the Year" by the editors of the journal Science . This protein plays a major role in cell growth. The job of P53 is to prevent (suppress) cells from growing. When it has been damaged or altered, P53 loses its ability to block cell growth. Changes to the gene result in an increased risk of cancer. Almost 50% of all human cancer cells contain a P53 mutation. These cancers are more aggressive and more often fatal. Since P53 is so important for normal cell growth in humans, researchers are continuing to look for ways to diagnose, prevent, and treat cancer associated with P53.
Mmmm..so how we can get this protein?
I found that , p53 is encoded by the TP53 gene located on the short arm of( chromosome 17 )
For these mammals, the gene is located on different chromosomes:
*( Chimp and orangutan, chromosome 17)
* Macaque, chromosome 16
* Mouse, chromosome 11
* Rat, chromosome 10
* Dog, chromosome 5
* Cow, chromosome 19
* Pig, chromosome 12
* Horse, chromosome 11
* Opossum, chromosome 2
Now we are looking for something that might increase levels of the properly functioning p53 gene.!!
Both cancer cells and cars need fuel to move but in cancer cell the fuel is Oxidative stress
Search for: ( oxidative stress)
You will find that oxidative stress is( imbalance between the production and manifestation of reactive oxygen species )
First ,I didn’t understand this definition but, later I understand that >
THERE'S SOMETHING CALLED (ROS)REACTIVE OXYGEN SPECIES ..WHICH IS molecules that carry oxygen such as peroxides BUT, why we descriped this molecule by REACTIVE?
They are reactive as they contain unpaired valence shell electrons. during times of environmental stress (e.g., UV or heat exposure), ROS levels can increase dramatically
(N.B)Normal cells have low levels of ROS, in tune with their more modest metabolism, so they don't need high levels of the anti-oxidant enzymes
SO ..>: cancer cell depends on a hyperactive metabolism to fuel its rapid growth, it also depends on anti-oxidative enzymes to get over or to quench potentially toxic reactive oxygen species (ROS) generated by such high metabolic demand
SO, we can find a compound that blocks this response to oxidative stress selectively in cancer cells
Then I found that Scientists at the Broad Institute and Massachusetts General Hospital (MGH) have discovered this compound that blocks this response to oxidative stress which isThe plant-based compound piperlongumine (PL), derived from the fruit of a pepper plant found in southern India and southeast Asia, appears to kill cancer cells by jamming the machinery that dissipates high oxidative stress and the resulting ROS. Normal cells have low levels of ROS, in tune with their more modest metabolism, so they don't need high levels of the anti-oxidant enzymes that PL stymies once they pass a certain threshold.
THEY saw that PL induced cancer cell death independent of p53 gene's activity.
What's p53?
P53..........(protein that in humans is encoded by the TP53 gene)...There are specific genes in the cells of our bodies that normally help to prevent tumors from forming. One of these tumor-suppressor genes , called P53 ("p" for protein and "53" for its weight) was recently named "Molecule of the Year" by the editors of the journal Science . This protein plays a major role in cell growth. The job of P53 is to prevent (suppress) cells from growing. When it has been damaged or altered, P53 loses its ability to block cell growth. Changes to the gene result in an increased risk of cancer. Almost 50% of all human cancer cells contain a P53 mutation. These cancers are more aggressive and more often fatal. Since P53 is so important for normal cell growth in humans, researchers are continuing to look for ways to diagnose, prevent, and treat cancer associated with P53.
Mmmm..so how we can get this protein?
I found that , p53 is encoded by the TP53 gene located on the short arm of( chromosome 17 )
For these mammals, the gene is located on different chromosomes:
*( Chimp and orangutan, chromosome 17)
* Macaque, chromosome 16
* Mouse, chromosome 11
* Rat, chromosome 10
* Dog, chromosome 5
* Cow, chromosome 19
* Pig, chromosome 12
* Horse, chromosome 11
* Opossum, chromosome 2
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